You can absolutely pay for your vacation using a different credit card than the one used at the time of booking. However, this may depend on the specific payment policies of the hotel, travel agency, or online booking platform. Always double-check the payment policy of the hotel or service provider before you travel. If you plan to use a different card, it's a good idea to contact the property or provider in advance to confirm that it’s acceptable. Bring your credit card(s) and valid ID with you to avoid any unexpected issues.